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Chinese Scientists Reveal Brain Circuit Mechanism Under Anxiogenic Situations

Researchers revealed a circuit mechanism, in which BNST modulated the NAc, exerting a direct effect on anxiety.

Content provided by Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

Stressors and stress responses are physical signs or symptoms. Previous studies suggested that the bed nucleus of the stria terminalis (BNST) is a critical node in the stress response neurocircuitry. 

Recent work on human drug addiction has also demonstrated the role of BNST in withdrawal-related anxiety and relapse, indicating an intrinsic link between this stress response region and the reward system. 

The nucleus accumbens (NAc) is a vital component in the reward circuitry, which responds to stress signals, and has a dominant effect on anxiety regulation.    

Since both BNST and NAc are engaged in stress-related disorders, what are the interactions between these two regions? 

Researchers from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences, for the first time, revealed a circuit mechanism, in which BNST modulated the NAc, exerting a direct effect on anxiety. Their study was published in Molecular Psychiatry on June 18.  

They used functional MRI signaling, GCaMP-based fiber photometry recording, genetically modified virus tracing and both optogenetic and chemogenetic neuronal manipulations. The results showed that in an anxious state, there was an increased functional connectivity between BNST and NAc.   

Parvalbumin (PV) neurons within the NAc shell (sNAc) exhibited high excitability in a chronic stress mouse model that displayed excessive maladaptive avoidance during anxiogenic stimuli. Activation of these accumbal PV neurons promoted an avoidance coping response in healthy mice.   

Moreover, a new GABAergic somatostatin (SOM) afferent from the anterior dorsal BNST (adBNST) was uncovered, which directly innervated sNAcPV neurons. Optogenetic activation of these GABAergic terminals in sNAc produced an anxiolytic effect, which was mediated by sNAcPV cells.   

Inhibitory projections from adBNST attenuated sNAcPV neurons on the chronically stressed mice, and thus, activation of these inhibitory inputs from adBNST to sNAc rescued the excessively anxious state of the stressed mice.  

“The results provide a potentially neurobiological basis for therapeutic interventions in pathological anxiety. It may also help to explain why anxiety and addiction are highly comorbid, although these two common psychiatric disorders engage in emotion and reward circuits, respectively,” said Prof. TU Jie. 

The paper A new GABAergic somatostatin projection from the BNST onto accumbal parvalbumin neurons controls anxiety is in Molecular Psychiatry.

2 comments on “Chinese Scientists Reveal Brain Circuit Mechanism Under Anxiogenic Situations

  1. Rebecca Parkers

    This is a very interesting topic to study, as our brain is a very important organ that plays a big role. I often visit psychologists and found a great option for myself online chat with a specialist. We are always in touch and they often help in times of stress. I have a hard job so it is important for me to get help on time and not to be in negative emotions.

  2. IrisDavidson

    So useful. With the help of I also wrote on such theme, and it was so interesting to find out such info!

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